MGST1
Gene Information
- Official Symbol: MGST1
- Official Name: microsomal glutathione S-transferase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 4257
- UniProt: P10620
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.
Pfam Domains GO Terms
Pfam Domains
| MAPEG |
GO Terms
| cellular response to lipid hydroperoxide |
| response to lipid hydroperoxide |
| prostaglandin-E synthase activity |
| cellular response to hydroperoxide |
| Leydig cell differentiation |
| glutathione binding |
| prostaglandin biosynthetic process |
| prostanoid biosynthetic process |
| response to hydroperoxide |
| glutathione peroxidase activity |
| glutathione derivative metabolic process |
| glutathione derivative biosynthetic process |
| glutathione transferase activity |
| protein homotrimerization |
| prostaglandin metabolic process |
| prostanoid metabolic process |
| unsaturated fatty acid biosynthetic process |
| icosanoid biosynthetic process |
| protein trimerization |
| glutathione metabolic process |
| peroxisomal membrane |
| azurophil granule membrane |
| apical part of cell |
| cellular oxidant detoxification |
| fatty acid derivative biosynthetic process |
| cellular detoxification |
| unsaturated fatty acid metabolic process |
| icosanoid metabolic process |
| fatty acid biosynthetic process |
| detoxification |
| xenobiotic metabolic process |
| male gonad development |
| development of primary male sexual characteristics |
| male sex differentiation |
| mitochondrial outer membrane |
| fatty acid derivative metabolic process |
| sulfur compound biosynthetic process |
| monocarboxylic acid biosynthetic process |
| cellular response to xenobiotic stimulus |
| cellular modified amino acid metabolic process |
| gonad development |
| cellular response to toxic substance |
| development of primary sexual characteristics |
| cellular response to oxidative stress |
| sex differentiation |
| response to xenobiotic stimulus |
| carboxylic acid biosynthetic process |
| organic acid biosynthetic process |
| response to lipopolysaccharide |
| fatty acid metabolic process |
| response to molecule of bacterial origin |
| protein homooligomerization |
| sulfur compound metabolic process |
| response to oxidative stress |
| reproductive structure development |
| reproductive system development |
| cofactor metabolic process |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| response to toxic substance |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| protein complex oligomerization |
| myeloid cell activation involved in immune response |
| peptide metabolic process |
| monocarboxylic acid metabolic process |
| lipid biosynthetic process |
| myeloid leukocyte activation |
| small molecule biosynthetic process |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| developmental process involved in reproduction |
| response to bacterium |
| regulated exocytosis |
| leukocyte mediated immunity |
| cellular amide metabolic process |
| exocytosis |
| response to lipid |
| protein homodimerization activity |
| carboxylic acid metabolic process |
| leukocyte activation |
| endoplasmic reticulum membrane |
| cellular lipid metabolic process |
| oxidation-reduction process |
| response to organonitrogen compound |
| oxoacid metabolic process |
| secretion by cell |
| endoplasmic reticulum |
| response to drug |
| organic acid metabolic process |
| export from cell |
| cellular response to oxygen-containing compound |
| cell activation |
| response to nitrogen compound |
| immune effector process |
| secretion |
| lipid metabolic process |
| mitochondrion |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| organonitrogen compound biosynthetic process |
| reproductive process |
| reproduction |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| cellular response to stress |
| small molecule metabolic process |
| protein-containing complex subunit organization |
| immune response |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17385
- Expression level (log2 read counts): 2.17
Expression Distribution
MGST1 Expression in NALM6 Cells: 2.17
