NCOA5

Entrez Summary: N/A
UniProt Summary: Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
TRAIL 5ng/ml R00 exp35	-2.61
TRAIL 50ng/ml R00 exp36	-2.51
TNF-alpha 44ng/ml R08 exp533	-2.27
Wortmannin 5μM R00 exp38	-1.94
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-1.84
Tunicamycin 0.04μM R07 exp418	-1.8
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.78
Etoposide 0.1μM R05 exp198	-1.73
TIC10 10μM R08 exp532	1.72
Methotrexate 0.01μM R08 exp501	1.74
SNS-032 15μM R08 exp443	1.76
Trientine 500μM R08 exp534	1.79
Ethanol 0.01 R05 exp234	1.8
UM0011500 10μM R05 exp246	2.39

Global Fraction of Cell Lines Where Essential: 5/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	2/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution