NEMF

Entrez Summary: This gene encodes a component of the ribosome quality control complex. The encoded protein facilitates the recognition and ubiquitination of stalled 60S subunits by the ubiquitin ligase listerin. A similar protein in fly functions as a tumor suppressor. [provided by RefSeq, Jul 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-2.61
Aphidicolin 0.4μM R08 exp440	-2.3
Cycloheximide 0.2μM R00 exp15	-2.07
Lead acetate 2000μM R08 exp498 no dilution day6	-1.87
Hydroxyurea 100μM R07 exp329	-1.84
3-Bromopyruvate 7μM R04 exp175	-1.8
Bortezomib 0.005μM R00 exp6	-1.8
Rucaparib 6.5μM R08 exp520	-1.75
CB-5083 0.4μM R08 exp468	-1.7
HMS-I2 1μM R06 exp286	1.71
MKC9989 10μM R03 exp133	1.77
Brefeldin A 0.02μM R00 exp8	2.07

Gene	Correlation
HGC6.3	0.441

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution