NSFL1C
Gene Information
- Official Symbol: NSFL1C
- Official Name: NSFL1 cofactor
- Aliases and Previous Symbols: N/A
- Entrez ID: 55968
- UniProt: Q9UNZ2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| UBX |
| SEP |
GO Terms
| VCP-NSFL1C complex |
| negative regulation of protein localization to centrosome |
| positive regulation of mitotic centrosome separation |
| regulation of mitotic centrosome separation |
| regulation of protein localization to centrosome |
| positive regulation of centrosome cycle |
| spindle pole centrosome |
| nuclear envelope reassembly |
| establishment of mitotic spindle orientation |
| establishment of mitotic spindle localization |
| establishment of spindle orientation |
| Golgi stack |
| establishment of spindle localization |
| intermediate filament cytoskeleton |
| spindle localization |
| positive regulation of mitotic nuclear division |
| nuclear envelope organization |
| regulation of centrosome cycle |
| autophagosome assembly |
| autophagosome organization |
| positive regulation of nuclear division |
| ubiquitin binding |
| ATPase binding |
| microtubule cytoskeleton organization involved in mitosis |
| phospholipid binding |
| negative regulation of cellular protein localization |
| establishment of cell polarity |
| chromosome |
| vacuole organization |
| membrane fusion |
| Golgi organization |
| nucleus organization |
| positive regulation of mitotic cell cycle |
| macroautophagy |
| regulation of mitotic nuclear division |
| regulation of microtubule cytoskeleton organization |
| regulation of nuclear division |
| establishment or maintenance of cell polarity |
| positive regulation of cytoskeleton organization |
| regulation of microtubule-based process |
| autophagy |
| process utilizing autophagic mechanism |
| positive regulation of cell cycle process |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| proteasomal protein catabolic process |
| establishment of organelle localization |
| positive regulation of cell cycle |
| endomembrane system organization |
| microtubule cytoskeleton organization |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| regulation of cellular protein localization |
| regulation of cytoskeleton organization |
| modification-dependent macromolecule catabolic process |
| organelle localization |
| proteolysis involved in cellular protein catabolic process |
| mitotic cell cycle process |
| cellular protein catabolic process |
| positive regulation of organelle organization |
| regulation of mitotic cell cycle |
| microtubule-based process |
| mitotic cell cycle |
| protein catabolic process |
| regulation of cell cycle process |
| organelle assembly |
| membrane organization |
| cellular macromolecule catabolic process |
| regulation of cellular localization |
| cell cycle process |
| regulation of protein localization |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| cytoskeleton organization |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| proteolysis |
| regulation of organelle organization |
| cell cycle |
| organic substance catabolic process |
| cellular catabolic process |
| establishment of localization in cell |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17703
- Expression level (log2 read counts): 5.61
Expression Distribution
NSFL1C Expression in NALM6 Cells: 5.61
