PDE1C
Gene Information
- Official Symbol: PDE1C
- Official Name: phosphodiesterase 1C
- Aliases and Previous Symbols: N/A
- Entrez ID: 5137
- UniProt: Q14123
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016].
- UniProt Summary: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 12114
- Expression level (log2 read counts): 1.93
PDE1C Expression in NALM6 Cells: 1.93
