Pfam Domains GO Terms
| RNA pol Rpb8 |
| RNA polymerase II activity |
| RNA polymerase I activity |
| RNA polymerase I complex |
| RNA polymerase II, core complex |
| RNA polymerase III activity |
| RNA polymerase III complex |
| transcription elongation from RNA polymerase I promoter |
| termination of RNA polymerase I transcription |
| 7-methylguanosine mRNA capping |
| 7-methylguanosine RNA capping |
| RNA capping |
| transcription initiation from RNA polymerase I promoter |
| transcription by RNA polymerase I |
| positive regulation of viral transcription |
| transcription by RNA polymerase III |
| protein-DNA complex |
| positive regulation of gene expression, epigenetic |
| regulation of viral transcription |
| somatic stem cell population maintenance |
| snRNA transcription by RNA polymerase II |
| snRNA transcription |
| DNA-templated transcription, termination |
| transcription-coupled nucleotide-excision repair |
| transcription elongation from RNA polymerase II promoter |
| positive regulation of type I interferon production |
| fibroblast growth factor receptor signaling pathway |
| regulation of gene silencing by miRNA |
| regulation of gene silencing by RNA |
| regulation of posttranscriptional gene silencing |
| DNA-templated transcription, elongation |
| ncRNA transcription |
| positive regulation of viral process |
| single-stranded DNA binding |
| cellular response to fibroblast growth factor stimulus |
| nucleotide-excision repair |
| response to fibroblast growth factor |
| regulation of type I interferon production |
| regulation of gene silencing |
| stem cell population maintenance |
| maintenance of cell number |
| transcription initiation from RNA polymerase II promoter |
| regulation of viral process |
| DNA-templated transcription, initiation |
| regulation of symbiosis, encompassing mutualism through parasitism |
| regulation of gene expression, epigenetic |
| RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| mRNA splicing, via spliceosome |
| RNA splicing, via transesterification reactions |
| RNA splicing |
| positive regulation of cytokine production |
| mRNA processing |
| transcription by RNA polymerase II |
| cellular response to growth factor stimulus |
| DNA repair |
| positive regulation of multi-organism process |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| response to growth factor |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| regulation of cytokine production |
| mRNA metabolic process |
| enzyme linked receptor protein signaling pathway |
| DNA metabolic process |
| regulation of multi-organism process |
| cellular response to DNA damage stimulus |
| RNA processing |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| cellular response to endogenous stimulus |
| organic cyclic compound biosynthetic process |
| response to endogenous stimulus |
| cellular nitrogen compound biosynthetic process |
| RNA metabolic process |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| positive regulation of multicellular organismal process |
| macromolecule biosynthetic process |
| positive regulation of gene expression |
| gene expression |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| A-366 10μM R03 exp115 | 1.7 |
| NFN1 0.4μM R03 exp99 | 1.72 |
| Adefovir 20μM R07 exp332 | 1.75 |
| GSK2606414 1μM R05 exp236 | 1.78 |
| Pomalidomide 20μM R07 exp391 | 2.13 |
| GSK-J4 1μM R07 exp362 | 2.25 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 19/28 |
| blood | 19/28 |
| bone | 14/25 |
| breast | 23/33 |
| central nervous system | 26/56 |
| cervix | 1/4 |
| colorectal | 11/17 |
| esophagus | 6/13 |
| fibroblast | 0/1 |
| gastric | 8/15 |
| kidney | 11/21 |
| liver | 14/20 |
| lung | 43/75 |
| lymphocyte | 9/14 |
| ovary | 19/26 |
| pancreas | 20/24 |
| peripheral nervous system | 10/16 |
| plasma cell | 7/15 |
| prostate | 1/1 |
| skin | 9/24 |
| soft tissue | 3/7 |
| thyroid | 1/2 |
| upper aerodigestive | 11/22 |
| urinary tract | 19/29 |
| uterus | 4/5 |
Expression Distribution