PPP1R12A
Gene Information
- Official Symbol: PPP1R12A
- Official Name: protein phosphatase 1 regulatory subunit 12A
- Aliases and Previous Symbols: N/A
- Entrez ID: 4659
- UniProt: O14974
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN- dependent suppression of HIF1A activity. {ECO:0000269|PubMed:18477460, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:20354225}.
Pfam Domains GO Terms
Pfam Domains
| Ank |
| Ank 2 |
GO Terms
| positive regulation of myosin-light-chain-phosphatase activity |
| contractile fiber |
| PTW/PP1 phosphatase complex |
| regulation of myosin-light-chain-phosphatase activity |
| phosphatase regulator activity |
| A band |
| regulation of endothelial cell development |
| regulation of establishment of endothelial barrier |
| positive regulation of phosphoprotein phosphatase activity |
| 14-3-3 protein binding |
| enzyme inhibitor activity |
| regulation of endothelial cell differentiation |
| positive regulation of phosphatase activity |
| positive regulation of protein dephosphorylation |
| positive regulation of dephosphorylation |
| centrosome cycle |
| kinetochore |
| microtubule organizing center organization |
| regulation of nucleocytoplasmic transport |
| regulation of phosphoprotein phosphatase activity |
| G2/M transition of mitotic cell cycle |
| Z disc |
| cell cycle G2/M phase transition |
| regulation of protein dephosphorylation |
| regulation of epithelial cell differentiation |
| regulation of phosphatase activity |
| regulation of dephosphorylation |
| protein dephosphorylation |
| actin cytoskeleton |
| mitotic cell cycle phase transition |
| cell cycle phase transition |
| dephosphorylation |
| regulation of intracellular transport |
| cellular response to drug |
| focal adhesion |
| protein kinase binding |
| microtubule cytoskeleton organization |
| centrosome |
| mitotic cell cycle process |
| microtubule-based process |
| regulation of cell adhesion |
| mitotic cell cycle |
| positive regulation of hydrolase activity |
| negative regulation of catalytic activity |
| regulation of cellular localization |
| regulation of cell development |
| cell cycle process |
| response to drug |
| cytoskeleton organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| cell cycle |
| positive regulation of catalytic activity |
| positive regulation of transcription, DNA-templated |
| positive regulation of cellular protein metabolic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 539/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 25/28 |
| blood | 14/28 |
| bone | 18/26 |
| breast | 22/33 |
| central nervous system | 45/56 |
| cervix | 4/4 |
| colorectal | 16/17 |
| esophagus | 12/13 |
| fibroblast | 1/1 |
| gastric | 15/16 |
| kidney | 15/21 |
| liver | 11/20 |
| lung | 50/75 |
| lymphocyte | 9/16 |
| ovary | 21/26 |
| pancreas | 17/24 |
| peripheral nervous system | 6/16 |
| plasma cell | 8/15 |
| prostate | 0/1 |
| skin | 13/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 20/22 |
| urinary tract | 24/29 |
| uterus | 4/5 |
Essentiality in NALM6
- Essentiality Rank: 1553
- Expression level (log2 read counts): 6.89
Expression Distribution
PPP1R12A Expression in NALM6 Cells: 6.89
