PRMT5
Gene Information
- Official Symbol: PRMT5
- Official Name: protein arginine methyltransferase 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 10419
- UniProt: O14744
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| PRMT5 |
GO Terms
| positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway |
| regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway |
| peptidyl-arginine methylation, to symmetrical-dimethyl arginine |
| protein-arginine omega-N symmetric methyltransferase activity |
| histone methyltransferase activity (H4-R3 specific) |
| positive regulation of dopamine receptor signaling pathway |
| histone H4-R3 methylation |
| protein-arginine N-methyltransferase activity |
| histone-arginine N-methyltransferase activity |
| peptidyl-arginine omega-N-methylation |
| endothelial cell activation |
| positive regulation of cellular response to drug |
| peptidyl-arginine N-methylation |
| regulation of dopamine receptor signaling pathway |
| Golgi ribbon formation |
| methylosome |
| histone arginine methylation |
| peptidyl-arginine methylation |
| positive regulation of oligodendrocyte differentiation |
| regulation of DNA methylation |
| methyl-CpG binding |
| peptidyl-arginine modification |
| positive regulation of G protein-coupled receptor signaling pathway |
| liver regeneration |
| positive regulation of response to drug |
| ribonucleoprotein complex binding |
| regulation of cellular response to drug |
| spliceosomal snRNP assembly |
| regulation of oligodendrocyte differentiation |
| histone methyltransferase complex |
| positive regulation of glial cell differentiation |
| E-box binding |
| methyltransferase activity |
| circadian regulation of gene expression |
| p53 binding |
| regulation of glial cell differentiation |
| positive regulation of gliogenesis |
| DNA-templated transcription, termination |
| animal organ regeneration |
| histone methylation |
| regulation of response to drug |
| regulation of gliogenesis |
| liver development |
| hepaticobiliary system development |
| Golgi organization |
| protein methylation |
| protein alkylation |
| circadian rhythm |
| regulation of G protein-coupled receptor signaling pathway |
| regeneration |
| regulation of mitotic nuclear division |
| regulation of signal transduction by p53 class mediator |
| regulation of nuclear division |
| ribonucleoprotein complex assembly |
| transcription corepressor activity |
| ribonucleoprotein complex subunit organization |
| macromolecule methylation |
| rhythmic process |
| regulation of ERK1 and ERK2 cascade |
| RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| mRNA splicing, via spliceosome |
| RNA splicing, via transesterification reactions |
| methylation |
| regulation of DNA metabolic process |
| histone modification |
| covalent chromatin modification |
| RNA splicing |
| gland development |
| endomembrane system organization |
| ribonucleoprotein complex biogenesis |
| positive regulation of neurogenesis |
| mRNA processing |
| protein heterodimerization activity |
| positive regulation of nervous system development |
| positive regulation of cell development |
| regulation of mitotic cell cycle |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| mRNA metabolic process |
| chromatin organization |
| negative regulation of cell differentiation |
| regulation of MAPK cascade |
| regulation of cell cycle process |
| regulation of neurogenesis |
| cellular protein-containing complex assembly |
| RNA processing |
| peptidyl-amino acid modification |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| positive regulation of cell differentiation |
| Golgi apparatus |
| chromosome organization |
| identical protein binding |
| cell activation |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| regulation of cell cycle |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| regulation of organelle organization |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| negative regulation of biosynthetic process |
| protein-containing complex assembly |
| regulation of phosphorylation |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of signal transduction |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of multicellular organismal process |
| macromolecule biosynthetic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HARS | 0.436 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 638/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 1/1 |
| bile duct | 23/28 |
| blood | 26/28 |
| bone | 21/25 |
| breast | 27/33 |
| central nervous system | 53/56 |
| cervix | 4/4 |
| colorectal | 16/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 13/15 |
| kidney | 20/21 |
| liver | 18/20 |
| lung | 67/75 |
| lymphocyte | 12/14 |
| ovary | 20/26 |
| pancreas | 24/24 |
| peripheral nervous system | 14/16 |
| plasma cell | 14/15 |
| prostate | 1/1 |
| skin | 21/24 |
| soft tissue | 5/7 |
| thyroid | 2/2 |
| upper aerodigestive | 19/22 |
| urinary tract | 27/29 |
| uterus | 4/5 |
Essentiality in NALM6
- Essentiality Rank: 24
- Expression level (log2 read counts): 7.12
Expression Distribution
PRMT5 Expression in NALM6 Cells: 7.12
