RERG

Entrez Summary: N/A
UniProt Summary: Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential. {ECO:0000269|PubMed:11533059}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.11μM R07 exp409	-1.93
Cycloheximide 0.02μM R00 exp14	-1.9
UM0125461 0.74μM R02 exp84	-1.81
UNC1999 2μM R03 exp155	1.73
Oligomycin-A 2μM R00 exp25	1.76
Arsenate 40μM R06 exp264	1.8
Betulinic acid 10 to 15μM on day4 R05 exp222	1.82
Caffeine 2600μM R08 exp463	1.84
Bafilomycin-A1 0.009μM R08 exp454	1.87
SB203580 25μM R03 exp149	1.87
Bisphenol F 50μM R08 exp457	2.12

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution