RNF121
Gene Information
- Official Symbol: RNF121
- Official Name: ring finger protein 121
- Aliases and Previous Symbols: N/A
- Entrez ID: 55298
- UniProt: Q9H920
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| zf-rbx1 |
GO Terms
| ubiquitin-dependent ERAD pathway |
| ERAD pathway |
| endoplasmic reticulum unfolded protein response |
| cellular response to unfolded protein |
| cellular response to topologically incorrect protein |
| response to unfolded protein |
| response to topologically incorrect protein |
| ubiquitin protein ligase activity |
| response to endoplasmic reticulum stress |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| proteasomal protein catabolic process |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| proteolysis involved in cellular protein catabolic process |
| Golgi membrane |
| cellular protein catabolic process |
| protein catabolic process |
| protein ubiquitination |
| protein modification by small protein conjugation |
| cellular macromolecule catabolic process |
| endoplasmic reticulum membrane |
| protein modification by small protein conjugation or removal |
| response to organonitrogen compound |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| response to nitrogen compound |
| proteolysis |
| cellular response to stress |
| organic substance catabolic process |
| cellular catabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Trientine 500μM R08 exp534 | -1.95 |
| Atovaquone 15μM R08 exp451 | -1.75 |
| 1-Methyl-nicotinamide-chloride 1000μM R03 exp113 | 1.75 |
| Wiskostatin 3μM R07 exp422 | 1.97 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| SLC38A7 | 0.508 |
| CBWD5 | 0.486 |
| CBWD3 | 0.482 |
| CBWD6 | 0.482 |
| ZFAND5 | 0.465 |
| HIST2H2BF | 0.455 |
| POLR2D | 0.452 |
| SUPT6H | 0.444 |
| NOP16 | 0.439 |
| DDX56 | 0.438 |
| MT1E | 0.437 |
| OGFR | 0.435 |
| RUVBL2 | 0.435 |
| POLA1 | 0.433 |
| PSMD3 | 0.433 |
| TWISTNB | 0.433 |
| MED17 | 0.429 |
| COPG1 | 0.422 |
| HAP1 | 0.421 |
| POLR2J3 | 0.42 |
| SSH2 | 0.418 |
| CHD4 | 0.417 |
| SMG1 | 0.413 |
| PSMC2 | 0.412 |
| GOLGA6L6 | 0.409 |
| PSMD11 | 0.406 |
| NBPF10 | 0.406 |
| PSMA6 | 0.405 |
| FAM160A1 | 0.405 |
| FAM86B2 | 0.405 |
| POLA2 | 0.403 |
| PSMB4 | 0.403 |
| MYB | 0.4 |
| TP53TG3B | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2111
- Expression level (log2 read counts): 4.49
Expression Distribution
RNF121 Expression in NALM6 Cells: 4.49
