SLU7

Entrez Summary: N/A
UniProt Summary: Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. {ECO:0000269|PubMed:10197984, ECO:0000269|PubMed:10647016, ECO:0000269|PubMed:12764196, ECO:0000269|PubMed:15728250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Gene	Correlation
RRM1	0.428

Global Fraction of Cell Lines Where Essential: 691/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	27/28
bone	24/26
breast	30/33
central nervous system	52/56
cervix	3/4
colorectal	17/17
esophagus	13/13
fibroblast	0/1
gastric	16/16
kidney	15/21
liver	19/20
lung	67/75
lymphocyte	16/16
ovary	24/26
pancreas	22/24
peripheral nervous system	16/16
plasma cell	14/15
prostate	1/1
skin	22/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	27/29
uterus	4/5

Expression Distribution