SRSF5
Gene Information
- Official Symbol: SRSF5
- Official Name: serine and arginine rich splicing factor 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 6430
- UniProt: Q13243
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.
Pfam Domains GO Terms
Pfam Domains
| RRM 1 |
GO Terms
| protein kinase B binding |
| liver regeneration |
| mRNA splice site selection |
| mRNA cis splicing, via spliceosome |
| positive regulation of RNA splicing |
| spliceosomal complex assembly |
| regulation of alternative mRNA splicing, via spliceosome |
| animal organ regeneration |
| mRNA 3-end processing |
| regulation of mRNA splicing, via spliceosome |
| mRNA export from nucleus |
| mRNA-containing ribonucleoprotein complex export from nucleus |
| ribonucleoprotein complex export from nucleus |
| ribonucleoprotein complex localization |
| liver development |
| RNA export from nucleus |
| hepaticobiliary system development |
| RNA 3-end processing |
| regulation of RNA splicing |
| regulation of mRNA processing |
| protein export from nucleus |
| mRNA transport |
| regeneration |
| nuclear export |
| cellular response to insulin stimulus |
| nucleic acid transport |
| RNA transport |
| establishment of RNA localization |
| RNA localization |
| response to insulin |
| ribonucleoprotein complex assembly |
| nucleobase-containing compound transport |
| ribonucleoprotein complex subunit organization |
| protein-containing complex localization |
| nucleocytoplasmic transport |
| cellular response to peptide hormone stimulus |
| nuclear transport |
| RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| mRNA splicing, via spliceosome |
| RNA splicing, via transesterification reactions |
| cellular response to peptide |
| regulation of mRNA metabolic process |
| response to peptide hormone |
| RNA splicing |
| nuclear speck |
| gland development |
| ribonucleoprotein complex biogenesis |
| response to peptide |
| mRNA processing |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| cellular response to nitrogen compound |
| mRNA metabolic process |
| cellular protein-containing complex assembly |
| nucleolus |
| RNA processing |
| response to hormone |
| intracellular protein transport |
| response to organonitrogen compound |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| regulation of cell cycle |
| cellular response to endogenous stimulus |
| RNA binding |
| response to endogenous stimulus |
| protein transport |
| intracellular transport |
| peptide transport |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| RNA metabolic process |
| positive regulation of RNA metabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of gene expression |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Ethanol 0.01 R05 exp234 | -2.54 |
| Bortezomib 0.005μM R00 exp6 | -2.39 |
| Quercetin 20μM R08 exp517 | -2.23 |
| LY2090314 0.003μM R08 exp499 | -2.08 |
| Golgicide-A 4μM R03 exp122 | -2.07 |
| Cyclosporin-A 0.8μM R07 exp347 | -1.86 |
| Dynasore 10μM R04 exp180 | -1.85 |
| THZ531 0.225μM R08 exp444 | -1.82 |
| BML-284 0.09μM R08 exp460 | -1.75 |
| ZLN024 50μM R08 exp538 | -1.75 |
| Bisphenol A 100μM R06 exp269 | -1.72 |
| THZ531 0.11 to 0.175μM on day4 R07 exp413 | -1.72 |
| Arsenate 40μM R06 exp264 | 3.74 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6923
- Expression level (log2 read counts): 8.29
Expression Distribution
SRSF5 Expression in NALM6 Cells: 8.29
