ST20
Gene Information
- Official Symbol: ST20
- Official Name: suppressor of tumorigenicity 20
- Aliases and Previous Symbols: N/A
- Entrez ID: 400410
- UniProt: Q9HBF5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: N/A
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May act as a tumor suppressor. Promotes apoptosis of cancer cells. {ECO:0000269|PubMed:11857354}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| positive regulation of apoptotic DNA fragmentation |
| positive regulation of DNA catabolic process |
| cellular response to UV-C |
| regulation of apoptotic DNA fragmentation |
| regulation of DNA catabolic process |
| positive regulation of execution phase of apoptosis |
| cysteine-type endopeptidase activator activity involved in apoptotic process |
| response to UV-C |
| regulation of execution phase of apoptosis |
| cellular response to UV |
| activation of cysteine-type endopeptidase activity involved in apoptotic process |
| cellular response to light stimulus |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| response to UV |
| positive regulation of cysteine-type endopeptidase activity |
| positive regulation of endopeptidase activity |
| cellular response to radiation |
| negative regulation of cell growth |
| positive regulation of peptidase activity |
| positive regulation of DNA metabolic process |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of growth |
| apoptotic signaling pathway |
| response to light stimulus |
| cellular response to environmental stimulus |
| cellular response to abiotic stimulus |
| regulation of DNA metabolic process |
| positive regulation of proteolysis |
| positive regulation of cellular catabolic process |
| regulation of cell growth |
| regulation of endopeptidase activity |
| positive regulation of catabolic process |
| response to radiation |
| regulation of peptidase activity |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| regulation of growth |
| positive regulation of cell death |
| regulation of proteolysis |
| positive regulation of hydrolase activity |
| regulation of cellular catabolic process |
| apoptotic process |
| regulation of catabolic process |
| programmed cell death |
| cell death |
| response to abiotic stimulus |
| positive regulation of cellular component organization |
| regulation of hydrolase activity |
| positive regulation of catalytic activity |
| regulation of apoptotic process |
| regulation of programmed cell death |
| positive regulation of cellular protein metabolic process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| positive regulation of nucleobase-containing compound metabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14279
- Expression level (log2 read counts): 1.44
Expression Distribution
ST20 Expression in NALM6 Cells: 1.44
