TP53RK
Gene Information
- Official Symbol: TP53RK
- Official Name: TP53 regulating kinase
- Aliases and Previous Symbols: N/A
- Entrez ID: 112858
- UniProt: Q96S44
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation. {ECO:0000250, ECO:0000269|PubMed:11546806}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 751
- Expression level (log2 read counts): 5.34
TP53RK Expression in NALM6 Cells: 5.34
