USPL1

Entrez Summary: N/A
UniProt Summary: SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (PubMed:22878415). Plays a key role in RNA polymerase-II- mediated snRNA transcription in the Cajal bodies (PubMed:24413172). Is a component of complexes that can bind to U snRNA genes (PubMed:24413172). {ECO:0000269|PubMed:22878415, ECO:0000269|PubMed:24413172}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
L-74142 5μM R03 exp131	1.7
Nifuroxazide 1μM R01 exp51	1.75

Global Fraction of Cell Lines Where Essential: 408/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	20/28
blood	13/28
bone	9/26
breast	13/33
central nervous system	36/56
cervix	4/4
colorectal	7/17
esophagus	7/13
fibroblast	1/1
gastric	10/16
kidney	10/21
liver	13/20
lung	45/75
lymphocyte	5/16
ovary	16/26
pancreas	13/24
peripheral nervous system	9/16
plasma cell	10/15
prostate	0/1
skin	13/24
soft tissue	5/9
thyroid	1/2
upper aerodigestive	12/22
urinary tract	16/29
uterus	5/5

Expression Distribution