WDR46

Entrez Summary: N/A
UniProt Summary: Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus. {ECO:0000269|PubMed:23848194}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-6727 0.04μM R03 exp98	-2.01
Wiskostatin 3μM R07 exp422	1.7
PF-06409577 20μM R07 exp389	1.71
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.87
Alda-1 10μM R06 exp262	1.89
FBS-Wisent 0.1 R07 exp426	2.07
BI-D1870 2μM R04 exp162	2.15
Cidofovir 10μM R07 exp345	2.27
Cyclosporin-A 3μM R07 exp348	2.31
A-769662 20μM R07 exp331	2.42

Global Fraction of Cell Lines Where Essential: 103/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	7/28
blood	1/28
bone	6/26
breast	3/33
central nervous system	3/56
cervix	1/4
colorectal	3/17
esophagus	2/13
fibroblast	0/1
gastric	2/16
kidney	6/21
liver	1/20
lung	12/75
lymphocyte	3/16
ovary	1/26
pancreas	7/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	5/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	7/22
urinary tract	3/29
uterus	0/5

Expression Distribution