WRB

Entrez Summary: N/A
UniProt Summary: Receptor for ASNA1/TRC40-mediated insertion of tail- anchored (TA) proteins into the ER membrane. {ECO:0000269|PubMed:21444755}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cerivastatin 0.15μM R05 exp226	-2.6
Beta-Estradiol 0.55μM R07 exp425	-2.28
GSK591 2.6μM R03 exp128	-1.9
MLN-4924 0.2μM R00 exp21	-1.89
NN-Dimethylsphingosine 2.5μM R08 exp508	-1.88
Demecolcine 0.03μM R05 exp228	-1.84
Taxol 0.004μM R03 exp103	-1.8
A-769662 20μM R07 exp331	-1.76
ABT-702 0.1μM R06 exp260	-1.74
HMS-I2 1μM R06 exp286	-1.72
Thimerosal 0.85μM R08 exp529	1.81
∆-9-Tetrahydrocannabinol 30μM R08 exp445	2.15

Global Fraction of Cell Lines Where Essential: 104/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	7/28
blood	2/28
bone	3/26
breast	5/33
central nervous system	10/56
cervix	0/4
colorectal	7/17
esophagus	4/13
fibroblast	0/1
gastric	2/16
kidney	8/21
liver	5/20
lung	13/75
lymphocyte	2/16
ovary	1/26
pancreas	3/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	4/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	4/22
urinary tract	7/29
uterus	1/5

Expression Distribution