Table of Contents

Vitamin-D3 40μM R08 exp536

Mechanism of Action

Steroid hormone, converted to active 1,25-dihydroxycholecalciferol (calcitriol), role in calcium homeostasis

Technical Notes

Protein References

  • PubChem Name: Cholecalciferol
  • Synonyms: Vitamin D3; Colecalciferol
  • CAS #: 67-97-0
  • PubChem CID: 5280795
  • IUPAC: (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol
  • INCHI Name: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
  • INCHI Key: QYSXJUFSXHHAJI-YRZJJWOYSA-N
  • Molecular Weight: 384.6
  • Canonical SMILES: CC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C
  • Isomeric SMILES: C[C@H](CCCC(C)C)[C@H]1CC[C@@H]\\2[C@@]1(CCC/C2=C\\C=C/3\\C[C@H](CCC3=C)O)C
  • Molecular Formula: SGQVYFGIIA F

Protein Supplier

  • Supplier Name: Toronto Research Chemicals
  • Catalog #: V676045
  • Lot #: 1-LXM-62-1

Protein Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C27H44O 385.34649; found 385.34677

Dose Response Curve

  • Platform ID: Vitamin_D3
  • Min: -4.9823; Max: 99.7060





IC Concentration (µM)
IC10 43.1100
IC20 49.9600
IC30 55.1000
IC40 59.7100
IC50 64.2800
IC60 69.2000
IC70 74.9900
IC80 82.7100
IC90 95.8400


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
0/5ScoresViewViewViewViewView