ABCA1
Gene Information
- Official Symbol: ABCA1
- Official Name: ATP binding cassette subfamily A member 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 19
- UniProt: O95477
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| ABC tran |
| ABC2 membrane 3 |
GO Terms
| positive regulation of high-density lipoprotein particle assembly |
| phosphatidylserine floppase activity |
| regulation of high-density lipoprotein particle assembly |
| apolipoprotein A-I receptor activity |
| phosphatidylcholine floppase activity |
| anion transmembrane transporter activity |
| apolipoprotein A-I-mediated signaling pathway |
| apolipoprotein A-I binding |
| regulation of Cdc42 protein signal transduction |
| negative regulation of cholesterol storage |
| platelet dense granule organization |
| interleukin-1 beta secretion |
| high-density lipoprotein particle binding |
| phospholipid homeostasis |
| interleukin-1 secretion |
| phospholipid efflux |
| negative regulation of macrophage derived foam cell differentiation |
| high-density lipoprotein particle assembly |
| response to laminar fluid shear stress |
| interleukin-1 beta production |
| regulation of cholesterol storage |
| apolipoprotein binding |
| phospholipid transporter activity |
| reverse cholesterol transport |
| interleukin-1 production |
| intracellular cholesterol transport |
| positive regulation of cholesterol efflux |
| cellular response to cholesterol |
| intracellular sterol transport |
| cholesterol transfer activity |
| cellular response to low-density lipoprotein particle stimulus |
| negative regulation of lipid storage |
| cellular response to sterol |
| small GTPase binding |
| cholesterol efflux |
| regulation of cholesterol efflux |
| positive regulation of cholesterol transport |
| positive regulation of sterol transport |
| plasma lipoprotein particle assembly |
| response to cholesterol |
| response to lipoprotein particle |
| cellular response to lipoprotein particle stimulus |
| regulation of macrophage derived foam cell differentiation |
| protein-lipid complex assembly |
| response to sterol |
| lipid transporter activity |
| response to fluid shear stress |
| secretory granule organization |
| intracellular lipid transport |
| negative regulation of lipid localization |
| phospholipid translocation |
| plasma lipoprotein particle organization |
| lipid translocation |
| regulation of lipid storage |
| regulation of cholesterol transport |
| regulation of sterol transport |
| protein-lipid complex subunit organization |
| cytokine secretion |
| cholesterol binding |
| regulation of membrane lipid distribution |
| ATPase-coupled transmembrane transporter activity |
| cholesterol transport |
| syntaxin binding |
| anion homeostasis |
| endocytic vesicle |
| lytic vacuole organization |
| lysosome organization |
| phagocytic vesicle |
| positive regulation of lipid transport |
| sterol transport |
| cellular response to retinoic acid |
| regulation of plasma lipoprotein particle levels |
| cholesterol homeostasis |
| ATPase binding |
| sterol homeostasis |
| positive regulation of lipid localization |
| cellular response to alcohol |
| protein lipidation |
| lipoprotein biosynthetic process |
| phospholipid transport |
| phospholipid binding |
| regulation of lipid transport |
| response to retinoic acid |
| cholesterol metabolic process |
| lipoprotein metabolic process |
| organophosphate ester transport |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| secondary alcohol metabolic process |
| phagocytosis, engulfment |
| vacuole organization |
| lipid homeostasis |
| sterol metabolic process |
| regulation of lipid localization |
| organic hydroxy compound transport |
| plasma membrane invagination |
| regulation of Rho protein signal transduction |
| membrane invagination |
| cAMP-mediated signaling |
| cytokine production |
| protein secretion |
| establishment of protein localization to extracellular region |
| protein localization to extracellular region |
| cyclic-nucleotide-mediated signaling |
| peptide secretion |
| cellular response to lipopolysaccharide |
| cellular response to molecule of bacterial origin |
| cellular response to acid chemical |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| response to nutrient |
| cellular response to biotic stimulus |
| membrane raft |
| endosomal transport |
| response to alcohol |
| ATPase activity |
| regulation of Ras protein signal transduction |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| positive regulation of protein complex assembly |
| steroid metabolic process |
| endosome |
| anion transmembrane transport |
| lipid transport |
| vesicle organization |
| response to lipopolysaccharide |
| alcohol metabolic process |
| lipid localization |
| response to molecule of bacterial origin |
| phagocytosis |
| signaling receptor binding |
| second-messenger-mediated signaling |
| regulation of small GTPase mediated signal transduction |
| response to acid chemical |
| extracellular structure organization |
| external side of plasma membrane |
| regulation of lipid metabolic process |
| endomembrane system organization |
| regulation of protein complex assembly |
| organic hydroxy compound metabolic process |
| organic anion transport |
| response to nutrient levels |
| positive regulation of cellular component biogenesis |
| cellular response to lipid |
| response to extracellular stimulus |
| cellular response to organic cyclic compound |
| endocytosis |
| anion transport |
| import into cell |
| intracellular membrane-bounded organelle |
| response to bacterium |
| perinuclear region of cytoplasm |
| negative regulation of cell differentiation |
| ion homeostasis |
| response to lipid |
| membrane organization |
| response to organic cyclic compound |
| endoplasmic reticulum membrane |
| negative regulation of developmental process |
| ion transmembrane transport |
| regulation of cellular component biogenesis |
| Golgi apparatus |
| positive regulation of transport |
| response to organonitrogen compound |
| secretion by cell |
| response to drug |
| export from cell |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| chemical homeostasis |
| secretion |
| positive regulation of cellular component organization |
| lipid metabolic process |
| transmembrane transport |
| response to other organism |
| response to external biotic stimulus |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| ion transport |
| integral component of plasma membrane |
| organonitrogen compound biosynthetic process |
| response to endogenous stimulus |
| ATP binding |
| protein transport |
| intracellular transport |
| peptide transport |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| amide transport |
| establishment of protein localization |
| homeostatic process |
| intracellular signal transduction |
| cellular macromolecule biosynthetic process |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| macromolecule biosynthetic process |
| regulation of cell differentiation |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| regulation of transport |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15314
- Expression level (log2 read counts): 7.68
Expression Distribution
ABCA1 Expression in NALM6 Cells: 7.68
