ABR

Gene Information

Official Symbol: ABR
Official Name: ABR activator of RhoGEF and GTPase
Aliases and Previous Symbols: N/A
Entrez ID: 29
UniProt: Q12979
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13254
Expression level (log2 read counts): 2.18

Expression Distribution

Screen	Score
WNT3A 44ng/ml R08 exp537	-2.02
UNC2400 2μM R03 exp156	-1.72
42°C R08 exp539	1.88
Sulforaphane 9μM R08 exp525	1.93

RhoGAP
PH
C2
RhoGEF

negative regulation of neutrophil degranulation
negative regulation of blood vessel remodeling
negative regulation of neutrophil activation
regulation of neutrophil degranulation
regulation of blood vessel remodeling
negative regulation of cellular extravasation
regulation of neutrophil activation
negative regulation of myeloid leukocyte mediated immunity
negative regulation of leukocyte degranulation
postsynaptic density, intracellular component
negative regulation of tissue remodeling
negative regulation of regulated secretory pathway
regulation of cellular extravasation
negative regulation of exocytosis
regulation of vascular permeability
negative regulation of leukocyte migration
negative regulation of leukocyte mediated immunity
regulation of leukocyte degranulation
neuromuscular process controlling balance
regulation of myeloid leukocyte mediated immunity
positive regulation of phagocytosis
Rho guanyl-nucleotide exchange factor activity
regulation of tissue remodeling
Schaffer collateral - CA1 synapse
regulation of phagocytosis
activation of GTPase activity
inner ear morphogenesis
guanyl-nucleotide exchange factor activity
neuromuscular process
ear morphogenesis
negative regulation of immune effector process
negative regulation of inflammatory response
regulation of Rho protein signal transduction
negative regulation of immune response
regulation of regulated secretory pathway
vascular process in circulatory system
negative regulation of leukocyte activation
inner ear development
regulation of leukocyte migration
negative regulation of cell activation