AIP

Entrez Summary: The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014].
UniProt Summary: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

GAF domain binding
aryl hydrocarbon receptor complex
negative regulation of cyclic-nucleotide phosphodiesterase activity
regulation of cyclic-nucleotide phosphodiesterase activity
aryl hydrocarbon receptor binding
protein maturation by protein folding
regulation of protein kinase A signaling
peptidyl-prolyl cis-trans isomerase activity
protein peptidyl-prolyl isomerization
interleukin-12-mediated signaling pathway
cellular response to interleukin-12
response to interleukin-12
protein targeting to mitochondrion
peptidyl-proline modification
establishment of protein localization to mitochondrion
protein localization to mitochondrion
xenobiotic metabolic process
unfolded protein binding
cellular response to xenobiotic stimulus
mitochondrial transport
protein maturation
protein folding
transcription coactivator activity
response to xenobiotic stimulus
transcription factor binding
protein targeting
establishment of protein localization to organelle
mitochondrion organization
negative regulation of hydrolase activity
cytokine-mediated signaling pathway
protein localization to organelle
negative regulation of catalytic activity
peptidyl-amino acid modification
intracellular protein transport
cellular response to cytokine stimulus
response to cytokine
negative regulation of molecular function
regulation of hydrolase activity
protein transport
intracellular transport