BIK

Entrez Summary: N/A
UniProt Summary: Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX. {ECO:0000269|PubMed:8521816}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Methoxyestradiol 0.2μM R01 exp40	-1.93
Bortezomib 0.005μM R00 exp6	1.74
Lead acetate 2000μM R08 exp497	1.81
Hippuristanol 0.12μM R08 exp488	1.85
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.86
Dorsomorphin 5μM R07 exp357	1.91
Latrunculin-B 10μM R07 exp374	2.21
Trichostatin-A 0.06μM R07 exp415	2.31
Ethanol 0.01 R05 exp234	2.69

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of protein homooligomerization
regulation of protein homooligomerization
positive regulation of protein oligomerization
positive regulation of release of cytochrome c from mitochondria
regulation of protein oligomerization
regulation of release of cytochrome c from mitochondria
apoptotic mitochondrial changes
endomembrane system
mitochondrial membrane
positive regulation of mitochondrion organization
male gonad development
development of primary male sexual characteristics
male sex differentiation
positive regulation of apoptotic signaling pathway
regulation of mitochondrion organization
gonad development
development of primary sexual characteristics
positive regulation of protein complex assembly
sex differentiation
regulation of apoptotic signaling pathway
reproductive structure development
reproductive system development
mitochondrion organization
regulation of protein complex assembly
positive regulation of cellular component biogenesis
positive regulation of organelle organization
positive regulation of apoptotic process
positive regulation of programmed cell death
developmental process involved in reproduction
positive regulation of cell death
apoptotic process
regulation of cellular component biogenesis
programmed cell death
cell death
positive regulation of cellular component organization
regulation of organelle organization
reproductive process
reproduction
regulation of apoptotic process
regulation of programmed cell death