DDI2

Entrez Summary: N/A
UniProt Summary: Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane (PubMed:27676298, PubMed:27528193). Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1 (PubMed:27528193). {ECO:0000269|PubMed:27528193, ECO:0000269|PubMed:27676298}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CB-5083 0.4μM R08 exp468	-3.76
Tubacin 1.6μM R07 exp416	-3.55
Docosahexaenoic-acid 50μM R07 exp356	-2.84
Thimerosal 0.85μM R08 exp529	-2.6
Arsenic trioxide 60μM R08 exp449	-2.55
IU1-47 25μM R04 exp182	-2.52
Artemisinin 50μM R08 exp450	-2.29
Bortezomib 0.005μM R00 exp6	-2.29
UM0125461 0.74μM R02 exp84	-1.99
Dynasore 10μM R04 exp180	-1.73
Oligomycin-A 2μM R00 exp25	1.7
LLY-283 2.6μM R06 exp290	1.88
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.91
FK-506 30μM R07 exp359	1.91
Etoposide 0.1μM R05 exp198	1.94
Erlotinib 10μM R05 exp216	2.3
Cycloheximide 0.2μM R00 exp15	2.45
Diepoxybutane 3μM R07 exp354	2.64
MK-1775 0.32μM R02 exp75	2.78

Global Fraction of Cell Lines Where Essential: 8/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	2/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
NGLY1	0.683
NFE2L1	0.57

regulation of DNA stability
cellular response to hydroxyurea
response to hydroxyurea
response to antimetabolite
aspartic-type endopeptidase activity
ubiquitin binding
response to antineoplastic agent
chromosome
protein processing
cellular response to inorganic substance
protein maturation
regulation of protein stability
proteasomal protein catabolic process
cellular response to drug
response to inorganic substance
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
cellular response to nitrogen compound
protein catabolic process
cellular macromolecule catabolic process
response to drug
macromolecule catabolic process
organonitrogen compound catabolic process
identical protein binding
response to nitrogen compound
proteolysis
organic substance catabolic process
cellular catabolic process
gene expression