EIF3H

Entrez Summary: N/A
UniProt Summary: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF- 3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03007, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dimethyloxaloylglycine 100μM R05 exp229	-3.14
Atovaquone 15μM R08 exp451	-2.44
42°C R08 exp539	-2.13
Torin1 0.08μM R02 exp82	-1.72
Nutlin-3A 1.6μM R06 exp294	1.76
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.78
THZ531 0.11 to 0.175μM on day4 R07 exp413	1.78
Dimethyloxaloylglycine 11μM R07 exp314	1.8
Pyridostatin 4μM R05 exp240	1.82
UM131593 0.1μM R01 exp58	1.88
AICAR 240μM R03 exp116	1.95
Citral 75μM R06 exp275	1.96
VER-155008 3.9μM R06 exp301	2.04
THZ531 0.225μM R08 exp444	2.05
Citral 50μM R06 exp274	2.31
∆-9-Tetrahydrocannabinol 30μM R08 exp445	2.31
Trientine 500μM R08 exp534	2.42
Vincristine 0.0005μM R04 exp190	2.48
THZ531 0.11 to 0.125μM on day4 R07 exp410	2.62
Doxorubicin 0.02μM R08 exp478	2.78
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	3.1
Thimerosal 0.85μM R08 exp529	3.34
ML-792 0.2μM R08 exp505	3.99
Arsenate 40μM R06 exp264	4.14

Global Fraction of Cell Lines Where Essential: 286/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	8/28
blood	6/28
bone	12/26
breast	11/33
central nervous system	30/56
cervix	1/4
colorectal	8/17
esophagus	2/13
fibroblast	1/1
gastric	5/16
kidney	4/21
liver	10/20
lung	27/75
lymphocyte	6/16
ovary	9/26
pancreas	9/24
peripheral nervous system	14/16
plasma cell	5/15
prostate	1/1
skin	13/24
soft tissue	3/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	9/29
uterus	2/5

Expression Distribution

eukaryotic translation initiation factor 3 complex, eIF3m
eukaryotic 48S preinitiation complex
eukaryotic translation initiation factor 3 complex
formation of cytoplasmic translation initiation complex
eukaryotic 43S preinitiation complex
cytoplasmic translational initiation
polysomal ribosome
translation initiation factor activity
metallopeptidase activity
cytoplasmic translation
regulation of translational initiation
translational initiation
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
regulation of translation
translation
regulation of cellular amide metabolic process
peptide biosynthetic process
ribonucleoprotein complex biogenesis
posttranscriptional regulation of gene expression
amide biosynthetic process
peptide metabolic process
cellular amide metabolic process
cellular protein-containing complex assembly
proteolysis
RNA binding
organonitrogen compound biosynthetic process
protein-containing complex assembly
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
membrane
gene expression