ENPP2

Entrez Summary: The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

alkylglycerophosphoethanolamine phosphodiesterase activity
nucleotide diphosphatase activity
phosphatidylcholine catabolic process
phosphodiesterase I activity
positive regulation of lamellipodium morphogenesis
regulation of lamellipodium morphogenesis
polysaccharide binding
glycerophospholipid catabolic process
lysophospholipase activity
positive regulation of lamellipodium organization
phospholipid catabolic process
regulation of lamellipodium organization
scavenger receptor activity
glycerolipid catabolic process
phosphatidylcholine metabolic process
hydrolase activity
organophosphate catabolic process
positive regulation of epithelial cell migration
positive regulation of peptidyl-tyrosine phosphorylation
ammonium ion metabolic process
nucleic acid binding
cellular lipid catabolic process
regulation of epithelial cell migration
regulation of peptidyl-tyrosine phosphorylation
regulation of angiogenesis
lipid catabolic process
nucleic acid phosphodiester bond hydrolysis
glycerophospholipid metabolic process
regulation of vasculature development
transcription factor binding
phospholipid metabolic process
glycerolipid metabolic process
positive regulation of cell projection organization
regulation of cell morphogenesis
positive regulation of cell migration
positive regulation of cell motility
positive regulation of cellular component movement
chemotaxis
taxis
positive regulation of locomotion