ETV3

Entrez Summary: N/A
UniProt Summary: Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. {ECO:0000269|PubMed:12007404}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
SB202190 10μM R03 exp148	-2.47
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.79
BI-D1870 3.15μM R02 exp66	-1.78
Tubacin 1.6μM R07 exp416	1.78
Selumetinib 20μM R02 exp81	1.8
Metformin 100 to 150μM on day4 R04 exp170	1.84
3-Bromopyruvate 7μM R04 exp175	1.9
Trametinib 10μM R02 exp83	2.68
Lead acetate 2000μM R08 exp497	2.8

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
RUVBL2	0.432
POLR2J3	0.406

RNA polymerase II transcription repressor complex
DEAD/H-box RNA helicase binding
response to granulocyte macrophage colony-stimulating factor
cellular response to granulocyte macrophage colony-stimulating factor stimulus
nuclear chromatin
DNA-binding transcription repressor activity, RNA polymerase II-specific
RNA polymerase II regulatory region sequence-specific DNA binding
negative regulation of cell population proliferation
molecular function
negative regulation of transcription by RNA polymerase II
cellular response to cytokine stimulus
response to cytokine
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
regulation of cell population proliferation
negative regulation of gene expression