EXTL1

Gene Information

Official Symbol: EXTL1
Official Name: exostosin like glycosyltransferase 1
Aliases and Previous Symbols: N/A
Entrez ID: 2134
UniProt: Q92935
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Probable glycosyltransferase. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Deguelin 0.05μM R02 exp69	-2.69
SB202190 10μM R03 exp148	-2.3
Talazoparib 0.006μM R06 exp299	-2.27
R-DABN 8μM R03 exp111	-1.89
BVD-523 15μM R02 exp67	-1.81
MS023 7μM R03 exp135	-1.77
S-DABN 8μM R03 exp112	-1.75
Dexamethasone 0.006μM R07 exp351	1.85
Hydroxychloroquine 30μM R08 exp490	2.03

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2696
Expression level (log2 read counts): -2.08

Expression Distribution

Glyco transf 64
Exostosin

glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
transferase activity, transferring glycosyl groups
acetylglucosaminyltransferase activity
glucuronosyltransferase activity
heparan sulfate proteoglycan biosynthetic process
heparan sulfate proteoglycan metabolic process
polysaccharide biosynthetic process
cellular polysaccharide biosynthetic process
IRE1-mediated unfolded protein response
cellular carbohydrate biosynthetic process
proteoglycan biosynthetic process
cellular polysaccharide metabolic process
polysaccharide metabolic process
proteoglycan metabolic process
glycosaminoglycan biosynthetic process
endoplasmic reticulum unfolded protein response
aminoglycan biosynthetic process
cellular response to unfolded protein
carbohydrate biosynthetic process
cellular response to topologically incorrect protein
glycosaminoglycan metabolic process
response to unfolded protein
aminoglycan metabolic process
cellular carbohydrate metabolic process
response to topologically incorrect protein
macromolecule glycosylation
protein glycosylation
response to endoplasmic reticulum stress
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate metabolic process
skeletal system development
carbohydrate derivative biosynthetic process
endoplasmic reticulum membrane
Golgi apparatus
endoplasmic reticulum
carbohydrate derivative metabolic process
organonitrogen compound biosynthetic process