HENMT1

Entrez Summary: N/A
UniProt Summary: Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis. {ECO:0000250|UniProtKB:Q8CAE2}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

RNA methyltransferase activity
O-methyltransferase activity
production of siRNA involved in RNA interference
P granule
RNA interference
piRNA metabolic process
production of small RNA involved in gene silencing by RNA
dsRNA processing
posttranscriptional gene silencing by RNA
posttranscriptional gene silencing
RNA methylation
gene silencing by RNA
gene silencing
RNA modification
regulation of gene expression, epigenetic
macromolecule methylation
methylation
ncRNA metabolic process
posttranscriptional regulation of gene expression
RNA processing
RNA binding
RNA metabolic process
negative regulation of gene expression
gene expression