KIN

Entrez Summary: N/A
UniProt Summary: Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro. {ECO:0000250|UniProtKB:Q8K339, ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485, ECO:0000269|PubMed:17045609}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
RO-3307 4.7μM R02 exp80	-1.83
B02 10μM R08 exp453	1.71
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.83
THZ531 0.11 to 0.125μM on day4 R07 exp410	1.86
THZ531 0.11 to 0.175μM on day4 R07 exp413	1.88
Rifampicin 10μM R00 exp32	1.89
Parthenolide 2.5μM R05 exp238	2.02
SGC2096 2.6μM R03 exp153	2.19

Global Fraction of Cell Lines Where Essential: 582/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	19/28
blood	21/28
bone	22/26
breast	20/33
central nervous system	45/56
cervix	3/4
colorectal	16/17
esophagus	11/13
fibroblast	1/1
gastric	14/16
kidney	12/21
liver	9/20
lung	60/75
lymphocyte	15/16
ovary	22/26
pancreas	19/24
peripheral nervous system	14/16
plasma cell	15/15
prostate	1/1
skin	23/24
soft tissue	6/9
thyroid	2/2
upper aerodigestive	18/22
urinary tract	20/29
uterus	4/5

Expression Distribution

double-stranded DNA binding
nuclear matrix
DNA replication
DNA recombination
mRNA processing
DNA repair
protein-containing complex
intracellular membrane-bounded organelle
mRNA metabolic process
viral process
DNA metabolic process
cellular response to DNA damage stimulus
symbiotic process
interspecies interaction between organisms
RNA processing
RNA binding
DNA binding
RNA metabolic process
cellular response to stress
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression