MICU2

Entrez Summary: N/A
UniProt Summary: Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:24503055, PubMed:24560927, PubMed:26903221). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering (PubMed:24560927). {ECO:0000269|PubMed:24503055, ECO:0000269|PubMed:24560927, ECO:0000269|PubMed:26387864, ECO:0000269|PubMed:26903221}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	1.73
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	1.74
Tubastatin-A 2.5μM R07 exp417	1.78
Cycloheximide 0.02μM R00 exp14	1.83
NMS-873 0.07μM R07 exp380	1.85
Salubrinal 20μM R07 exp399	1.86
Oligomycin-A 2μM R00 exp25	1.87
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	1.9
BI-6727 0.0125μM R03 exp97	1.93
ABT-702 0.1μM R06 exp260	1.94
Chlorpromazine 10μM R07 exp344	2
GSK461364A 0.005μM R03 exp125	2.01
Tubacin 1.6μM R07 exp416	2.17

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of mitochondrial calcium ion concentration
uniplex complex
calcium import into the mitochondrion
positive regulation of mitochondrial calcium ion concentration
mitochondrial calcium ion transmembrane transport
calcium channel complex
mitochondrial calcium ion homeostasis
calcium ion import
mitochondrial intermembrane space
cytosolic calcium ion transport
mitochondrial transmembrane transport
calcium ion transmembrane transport
mitochondrial transport
calcium ion transport
divalent metal ion transport
divalent inorganic cation transport
mitochondrial inner membrane
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
protein heterodimerization activity
divalent inorganic cation homeostasis
cellular metal ion homeostasis
inorganic cation transmembrane transport
cation transmembrane transport
metal ion homeostasis
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
inorganic ion transmembrane transport
cation homeostasis
inorganic ion homeostasis
calcium ion binding
cellular chemical homeostasis
ion homeostasis
cation transport
cellular homeostasis
ion transmembrane transport
chemical homeostasis
mitochondrion