NEK1

Entrez Summary: The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Pkinase
Pkinase Tyr

pericentriolar material
14-3-3 protein binding
DNA damage response, detection of DNA damage
kinase activity
protein tyrosine kinase activity
stress-activated protein kinase signaling cascade
peptidyl-tyrosine phosphorylation
peptidyl-tyrosine modification
protein kinase activity
activation of protein kinase activity
cilium assembly
protein serine/threonine kinase activity
cilium organization
signal transduction by protein phosphorylation
plasma membrane bounded cell projection assembly
cell projection assembly
centrosome
cell division
positive regulation of protein kinase activity
positive regulation of kinase activity
positive regulation of transferase activity
detection of stimulus
organelle assembly
cellular response to DNA damage stimulus
regulation of protein kinase activity
regulation of kinase activity
peptidyl-amino acid modification
protein phosphorylation
regulation of transferase activity
positive regulation of protein phosphorylation
positive regulation of phosphorylation
plasma membrane bounded cell projection organization
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
cell projection organization
positive regulation of protein modification process
phosphorylation
cell cycle
positive regulation of catalytic activity
regulation of protein phosphorylation