NEUROD1
Gene Information
- Official Symbol: NEUROD1
- Official Name: neuronal differentiation 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 4760
- UniProt: Q13562
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| HLH |
| Neuro bHLH |
GO Terms
| pancreatic A cell fate commitment |
| regulation of intestinal epithelial structure maintenance |
| pancreatic PP cell fate commitment |
| pancreatic PP cell differentiation |
| amacrine cell differentiation |
| negative regulation of type B pancreatic cell apoptotic process |
| pancreatic A cell differentiation |
| regulation of type B pancreatic cell apoptotic process |
| epithelial cell fate commitment |
| dentate gyrus development |
| signal transduction involved in regulation of gene expression |
| enteroendocrine cell differentiation |
| negative regulation of receptor signaling pathway via JAK-STAT |
| nitric oxide mediated signal transduction |
| negative regulation of receptor signaling pathway via STAT |
| positive regulation of transcription regulatory region DNA binding |
| glandular epithelial cell differentiation |
| endocrine pancreas development |
| insulin secretion |
| regulation of digestive system process |
| negative regulation of epithelial cell apoptotic process |
| E-box binding |
| regulation of transcription regulatory region DNA binding |
| RNA polymerase II activating transcription factor binding |
| positive regulation of DNA binding |
| neural retina development |
| peptide hormone secretion |
| cellular response to glucose stimulus |
| cellular response to hexose stimulus |
| RNA polymerase II transcription factor complex |
| cellular response to monosaccharide stimulus |
| hormone secretion |
| pancreas development |
| regulation of epithelial cell apoptotic process |
| cellular response to carbohydrate stimulus |
| hippocampus development |
| hormone transport |
| cellular glucose homeostasis |
| columnar/cuboidal epithelial cell differentiation |
| cerebellum development |
| regulation of cell cycle arrest |
| limbic system development |
| metencephalon development |
| endocrine system development |
| regulation of DNA binding |
| regulation of receptor signaling pathway via JAK-STAT |
| regulation of receptor signaling pathway via STAT |
| response to glucose |
| retina development in camera-type eye |
| response to hexose |
| response to monosaccharide |
| hindbrain development |
| protein secretion |
| establishment of protein localization to extracellular region |
| protein localization to extracellular region |
| signal release |
| response to carbohydrate |
| pallium development |
| peptide secretion |
| positive regulation of binding |
| regulation of insulin secretion |
| glucose homeostasis |
| carbohydrate homeostasis |
| inner ear development |
| regulation of peptide hormone secretion |
| anterior/posterior pattern specification |
| ear development |
| cell fate commitment |
| telencephalon development |
| positive regulation of DNA-binding transcription factor activity |
| nucleocytoplasmic transport |
| nuclear transport |
| regulation of hormone secretion |
| transcription coactivator activity |
| embryonic organ morphogenesis |
| camera-type eye development |
| regionalization |
| transcription factor binding |
| second-messenger-mediated signaling |
| eye development |
| visual system development |
| positive regulation of neuron differentiation |
| sensory system development |
| regulation of binding |
| forebrain development |
| chromatin binding |
| sequence-specific DNA binding |
| regulation of DNA-binding transcription factor activity |
| embryonic organ development |
| pattern specification process |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| regulation of protein secretion |
| positive regulation of neurogenesis |
| protein heterodimerization activity |
| regulation of peptide secretion |
| regulation of hormone levels |
| positive regulation of nervous system development |
| positive regulation of cell development |
| sensory organ development |
| embryonic morphogenesis |
| regulation of system process |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| regulation of neuron differentiation |
| DNA-binding transcription factor activity |
| epithelial cell differentiation |
| positive regulation of cell death |
| regulation of protein transport |
| regulation of peptide transport |
| brain development |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of cell cycle process |
| head development |
| regulation of secretion |
| neuron development |
| regulation of neurogenesis |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| regulation of nervous system development |
| regulation of cell development |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| embryo development |
| central nervous system development |
| negative regulation of cell death |
| secretion by cell |
| neuron differentiation |
| response to drug |
| regulation of protein localization |
| export from cell |
| cellular response to oxygen-containing compound |
| chemical homeostasis |
| epithelium development |
| cell-cell signaling |
| secretion |
| regulation of cell cycle |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| protein transport |
| intracellular transport |
| generation of neurons |
| peptide transport |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| amide transport |
| establishment of protein localization |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cell development |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of cell differentiation |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 1/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16379
- Expression level (log2 read counts): -0.65
Expression Distribution
NEUROD1 Expression in NALM6 Cells: -0.65
