NOB1

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BML-284 0.09μM R08 exp460	-1.94
Monensin 0.3μM R08 exp507	-1.79
Milciclib 2μM R08 exp502	-1.77
BI-2536 0.001μM R01 exp41	1.7
HMS-I2 1μM R06 exp286	1.73
6-Thio-2-deoxyguanosine 2μM R06 exp259	1.74
NFN1 0.1μM R01 exp49	1.74
Hypoxia 5%O2 R04 exp191	1.76
PT-1 25μM R07 exp392	1.76
BI-6727 0.001μM R01 exp42	1.9
Mubritinib 0.2μM R01 exp48	1.96
Arsenic trioxide 60μM R08 exp449	1.97
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	2
THZ531 0.11 to 0.175μM on day4 R07 exp413	2.12
GSK-J4 1-1.25μM to day4 R07 exp363	2.52
THZ531 0.225μM R08 exp444	3.4

Global Fraction of Cell Lines Where Essential: 609/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	22/28
blood	26/28
bone	24/26
breast	23/33
central nervous system	53/56
cervix	4/4
colorectal	10/17
esophagus	12/13
fibroblast	1/1
gastric	12/16
kidney	15/21
liver	16/20
lung	61/75
lymphocyte	14/16
ovary	20/26
pancreas	20/24
peripheral nervous system	16/16
plasma cell	11/15
prostate	1/1
skin	22/24
soft tissue	6/9
thyroid	2/2
upper aerodigestive	17/22
urinary tract	25/29
uterus	4/5

Expression Distribution

preribosome, small subunit precursor
cleavage involved in rRNA processing
endoribonuclease activity
maturation of SSU-rRNA
ribosomal small subunit biogenesis
RNA phosphodiester bond hydrolysis, endonucleolytic
RNA phosphodiester bond hydrolysis
rRNA processing
visual perception
rRNA metabolic process
sensory perception of light stimulus
nucleic acid phosphodiester bond hydrolysis
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
RNA processing
sensory perception
nervous system process
RNA metabolic process
system process
gene expression