PATZ1

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 1μM R00 exp29	-1.85
Rifampicin 1μM R00 exp31	-1.75
TRAIL 5ng/ml R00 exp35	1.73
TRAIL 50ng/ml R00 exp36	1.74
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	2.12
A-196 10μM R03 exp114	2.43

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

male gonad development
T cell differentiation
development of primary male sexual characteristics
male sex differentiation
gonad development
development of primary sexual characteristics
T cell activation
lymphocyte differentiation
sex differentiation
leukocyte differentiation
lymphocyte activation
chromatin binding
reproductive structure development
reproductive system development
DNA-binding transcription activator activity, RNA polymerase II-specific
RNA polymerase II proximal promoter sequence-specific DNA binding
spermatogenesis
hemopoiesis
male gamete generation
hematopoietic or lymphoid organ development
immune system development
developmental process involved in reproduction
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
leukocyte activation
multi-organism reproductive process
cell activation
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
reproductive process
reproduction
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process