S100A10

Gene Information

Official Symbol: S100A10
Official Name: S100 calcium binding protein A10
Aliases and Previous Symbols: N/A
Entrez ID: 6281
UniProt: P60903
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine- specific kinase.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
PT-1 25μM R07 exp392	-1.79
CR131-b 0.005μM R08 exp474	-1.72
Caffeine 2600μM R08 exp463	1.82
2-Methoxyestradiol 0.2μM R01 exp40	1.84
Daidzin 10μM R06 exp280	1.86
CVT-10216 0.1μM R06 exp278	1.99
Docetaxel 0.002μM R01 exp45	2.1

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13037
Expression level (log2 read counts): 2.46

Expression Distribution

membrane raft assembly
membrane raft organization
positive regulation of focal adhesion assembly
extrinsic component of plasma membrane
positive regulation of adherens junction organization
protein heterotetramerization
positive regulation of cell junction assembly
membrane assembly
positive regulation of substrate adhesion-dependent cell spreading
membrane biogenesis
positive regulation of cell-matrix adhesion
positive regulation of stress fiber assembly
regulation of substrate adhesion-dependent cell spreading
regulation of focal adhesion assembly
regulation of cell-substrate junction assembly
positive regulation of actin filament bundle assembly
regulation of adherens junction organization
regulation of stress fiber assembly
regulation of actomyosin structure organization
regulation of cell junction assembly
regulation of actin filament bundle assembly
vesicle budding from membrane
protein heterooligomerization
regulation of cell-matrix adhesion
positive regulation of cell-substrate adhesion
ion channel binding
protein tetramerization
lipid binding
positive regulation of cell morphogenesis involved in differentiation
positive regulation of binding
protein localization to plasma membrane
positive regulation of supramolecular fiber organization
regulation of cell-substrate adhesion
positive regulation of cytoskeleton organization
membrane raft
protein localization to cell periphery
regulation of actin filament organization
vesicle organization
regulation of cell morphogenesis involved in differentiation
regulation of actin cytoskeleton organization