SECISBP2

Entrez Summary: The protein encoded by this gene is one of the essential components of the machinery involved in co-translational insertion of selenocysteine (Sec) into selenoproteins. Sec is encoded by the UGA codon, which normally signals translation termination. The recoding of UGA as Sec codon requires a Sec insertion sequence (SECIS) element; present in the 3' untranslated regions of eukaryotic selenoprotein mRNAs. This protein specifically binds to the SECIS element, which is stimulated by a Sec-specific translation elongation factor. Mutations in this gene have been associated with reduction in enzymatic activity of type II iodothyronine deiodinase (a selenoprotein) and abnormal thyroid hormone metabolism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017].
UniProt Summary: Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Radicicol 0.16μM R05 exp242	-2.19
Artemisinin 50μM R08 exp450	-2.13
Senexin-A 25μM R07 exp400	-1.99
Palbociclib 1μM R07 exp382	-1.94
Vinblastine 0.015μM R05 exp208	-1.94
UM0130462 0.025 to 0.035μM day4 R05 exp247	-1.93
MLN-4924 2μM R00 exp22	-1.89
5-Fluorouracil 20μM R00 exp2	-1.88
Lead acetate 2000μM R08 exp498 no dilution day6	-1.83
GSK461364A 0.1μM R03 exp126	-1.79
Trientine 500μM R08 exp534	-1.76
Q15 2.7μM R02 exp79	1.72
MK-1775 0.32μM R02 exp75	1.97

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
selenocysteine insertion sequence binding
regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
selenocysteine incorporation
translational readthrough
striatum development
subpallium development
ribonucleoprotein complex binding
negative regulation of mRNA catabolic process
negative regulation of RNA catabolic process
mRNA 3-UTR binding
negative regulation of mRNA metabolic process
translational elongation
ribonucleoprotein complex
regulation of mRNA catabolic process
negative regulation of cellular catabolic process
telencephalon development
negative regulation of catabolic process
regulation of mRNA metabolic process
regulation of translation
translation
forebrain development
regulation of cellular amide metabolic process
peptide biosynthetic process
posttranscriptional regulation of gene expression
amide biosynthetic process
peptide metabolic process
brain development
head development
cellular amide metabolic process
neuron development
regulation of cellular catabolic process
central nervous system development
regulation of catabolic process
neuron differentiation
mitochondrion
negative regulation of RNA metabolic process
RNA binding
organonitrogen compound biosynthetic process
negative regulation of nucleobase-containing compound metabolic process