SLC11A2

Entrez Summary: This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-2.83
Momordin-Ic 10μM R08 exp506	-1.97
YM155 0.0002μM R01 exp61	-1.94
Trientine 500μM R08 exp534	-1.88
Hydroxyurea 100μM R07 exp329	-1.84
Rifampicin 10μM R00 exp32	-1.81
Deferoxamine 11μM R07 exp350	-1.78
Vinorelbine 0.001μM R05 exp249	-1.76
Curcumin 6.5μM R06 exp277	1.7
Disulfiram 4.3μM R06 exp281	1.71
Myriocin 25μM R06 exp293	1.72
VER-155008 3.9μM R06 exp301	1.74
CHIR-124 0.04μM R06 exp272	1.81
Bisphenol A 100μM R06 exp269	1.98
Lead acetate 2000μM R08 exp498 no dilution day6	2.01
HMS-I2 10μM R06 exp288	2.26
LLY-283 2.6μM R06 exp290	2.43

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
CYB561A3	0.422
GLRX3	0.414

nickel cation transmembrane transport
nickel cation transport
paraferritin complex
lead ion transmembrane transporter activity
nickel cation transmembrane transporter activity
cobalt ion transmembrane transporter activity
lead ion transport
transition metal ion transmembrane transporter activity
cadmium ion transmembrane transporter activity
solute:proton symporter activity
ferrous iron transmembrane transporter activity
manganese ion transmembrane transporter activity
cadmium ion transmembrane transport
iron import into cell
cadmium ion transport
copper ion transmembrane transporter activity
cobalt ion transport
cadmium ion binding
manganese ion transmembrane transport
copper ion transmembrane transport
iron ion transmembrane transporter activity
multicellular organismal iron ion homeostasis
manganese ion transport
vacuole
basal part of cell
iron ion transmembrane transport
copper ion transport
heme biosynthetic process
porphyrin-containing compound biosynthetic process
tetrapyrrole biosynthetic process
heme metabolic process
erythrocyte development
response to iron ion
porphyrin-containing compound metabolic process
pigment biosynthetic process
brush border membrane
extracellular vesicle
dendrite morphogenesis
myeloid cell development
tetrapyrrole metabolic process