TAF3

Gene Information

Official Symbol: TAF3
Official Name: TATA-box binding protein associated factor 3
Aliases and Previous Symbols: N/A
Entrez ID: 83860
UniProt: Q5VWG9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vemurafenib 6.6μM R08 exp434	-2.53
I-BRD9 4μM R07 exp365	-1.75
D-Fructose 10000μM R06 exp279	1.73
Disulfiram 4.3μM R06 exp281	1.74
Myriocin 25μM R06 exp293	1.83
Dynasore 7μM R08 exp436	2.01
Doxycycline 10μM R00 exp18	2.02
THZ531 0.225μM R08 exp444	2.1
Ethanol 0.01 R05 exp234	2.19
Aminopterin 0.005μM R07 exp335	2.22
Benzoate 20000μM R08 exp456	2.53
Quercetin 20μM R08 exp517	2.65
MLN-4924 0.2μM R00 exp21	3.77

Global Fraction of Cell Lines Where Essential: 5/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	3/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 405
Expression level (log2 read counts): 5.55

Expression Distribution

PHD
Bromo TP

maintenance of protein location in nucleus
transcription factor TFIID complex
maintenance of protein localization in organelle
p53 binding
maintenance of protein location in cell
maintenance of location in cell
maintenance of protein location
negative regulation of DNA-binding transcription factor activity
protein localization to nucleus
maintenance of location
transcription initiation from RNA polymerase II promoter
regulation of signal transduction by p53 class mediator
DNA-templated transcription, initiation
nuclear membrane
regulation of DNA-binding transcription factor activity
transcription by RNA polymerase II
protein heterodimerization activity
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
protein localization to organelle
negative regulation of transcription by RNA polymerase II
nucleobase-containing compound biosynthetic process
negative regulation of molecular function
heterocycle biosynthetic process
aromatic compound biosynthetic process
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
organic cyclic compound biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
cellular protein localization
cellular macromolecule localization
cellular nitrogen compound biosynthetic process
RNA metabolic process