TM2D1

Entrez Summary: N/A
UniProt Summary: May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42. {ECO:0000269|PubMed:11278849, ECO:0000269|PubMed:12836168}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.38
GSK591 2.6μM R03 exp128	-1.89
Benzoate 20000μM R08 exp456	-1.71
MLN-4924 0.2μM R00 exp21	1.8
3-Bromopyruvate 7μM R04 exp175	1.81
AICAR 240μM R03 exp116	1.86
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	1.88
Rapamycin 1μM R00 exp29	1.89
CCCP 0.1μM R00 exp10	1.95
Vinblastine 0.002μM R01 exp60	1.96
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	2.03
Arsenate 40μM R06 exp264	3.17

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

amyloid-beta binding
apoptotic signaling pathway
G protein-coupled receptor activity
apoptotic process
programmed cell death
cell death
G protein-coupled receptor signaling pathway
integral component of plasma membrane