WDR62

Entrez Summary: This gene is proposed to play a role in cerebral cortical development. Mutations in this gene have been associated with microencephaly, cortical malformations, and cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011].
UniProt Summary: Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20890278, PubMed:20729831). Plays a role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cabazitaxel 0.001μM R05 exp223	-3.68
Epothilone-B 0.0015μM R05 exp231	-3.66
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-2.33
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-2.21
S-trityl-L-cysteine 0.5μM R05 exp243	-1.86
Tozasertib 0.1μM R07 exp414	-1.79
Etoposide 0.3μM R05 exp199	1.84
Aminopterin 0.005μM R07 exp335	2
UMK57 1μM R01 exp59	2.02
Pimelic-diphenylamide-106 0.5μM R00 exp27	2.03
Mdivi-1 15μM R05 exp217	2.24

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
KATNA1	0.513
KATNB1	0.453

centriole replication
centriole assembly
centrosome duplication
mitotic spindle organization
centrosome cycle
microtubule organizing center organization
microtubule cytoskeleton organization involved in mitosis
cerebral cortex development
spindle pole
centriole
spindle organization
microtubule organizing center
pallium development
telencephalon development
forebrain development
microtubule cytoskeleton organization
centrosome
mitotic cell cycle process
microtubule-based process
mitotic cell cycle
brain development
organelle assembly
head development
central nervous system development
cell cycle process
cytoskeleton organization
cell cycle
neurogenesis