Nifurtimox 1μM R03 exp141
Mechanism of Action
Nitrofuran derivative, forms nitro-anion radical metabolite, induces ROS
- Class / Subclass 1: Infectious Disease / Antitrypanosomal
Technical Notes
Compound References
- PubChem Name: Nifurtimox
- Synonyms: N/A
- CAS #: 23256-30-6
- PubChem CID: 6842999
- IUPAC: (E)-N-(3-methyl-1,1-dioxo-1,4-thiazinan-4-yl)-1-(5-nitrofuran-2-yl)methanimine
- INCHI Name: InChI=1S/C10H13N3O5S/c1-8-7-19(16,17)5-4-12(8)11-6-9-2-3-10(18-9)13(14)15/h2-3,6,8H,4-5,7H2,1H3/b11-6+
- INCHI Key: ARFHIAQFJWUCFH-IZZDOVSWSA-N
- Molecular Weight: 287.29
- Canonical SMILES: CC1CS(=O)(=O)CCN1N=CC2=CC=C(O2)[N+](=O)[O-]
- Isomeric SMILES: CC1CS(=O)(=O)CCN1/N=C/C2=CC=C(O2)[N+](=O)[O-]
- Molecular Formula: C10H13N3O5S
Compound Supplier
- Supplier Name: Sigma-Aldrich
- Catalog #: N3415
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+COOH)- Calcd for C10 H13 N3 O5 S 332.05579; found 332.05672
Dose Response Curve
- Platform ID: RC-NFN5
- Min: -7.4928; Max: 14.3019
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 03
- Dose: 1µM
- Days of incubation: 8
- Doublings: 8.0
- Numbers of reads: 9780191
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/0 | Scores |
Nifurtimox 1μM R03 exp141
