PIH1D1
Gene Information
- Official Symbol: PIH1D1
- Official Name: PIH1 domain containing 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 55011
- UniProt: Q9NWS0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (PubMed:17636026). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (PubMed:22368283, PubMed:24036451). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (PubMed:20864032). Positively regulates the assembly and activity of the mTORC1 complex (PubMed:24036451). {ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:20864032, ECO:0000269|PubMed:22368283, ECO:0000269|PubMed:24036451}.
Pfam Domains GO Terms
Pfam Domains
| PIH1 |
GO Terms
| RNA polymerase I upstream control element sequence-specific DNA binding |
| negative regulation of histone H3-K9 dimethylation |
| positive regulation of glucose mediated signaling pathway |
| regulation of TORC2 signaling |
| negative regulation of histone H4-K16 acetylation |
| regulation of histone H3-K9 dimethylation |
| regulation of glucose mediated signaling pathway |
| R2TP complex |
| negative regulation of histone H3-K9 trimethylation |
| negative regulation of histone H4 acetylation |
| snoRNA localization |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| regulation of histone H4-K16 acetylation |
| pre-snoRNP complex |
| positive regulation of histone H4 acetylation |
| establishment of protein localization to chromatin |
| positive regulation of histone H3-K9 acetylation |
| RNA polymerase I CORE element sequence-specific DNA binding |
| RNA polymerase I preinitiation complex assembly |
| box C/D snoRNP assembly |
| positive regulation of transcription of nucleolar large rRNA by RNA polymerase I |
| small nucleolar ribonucleoprotein complex assembly |
| regulation of histone H3-K9 trimethylation |
| negative regulation of histone H3-K9 methylation |
| regulation of histone H4 acetylation |
| regulation of transcription of nucleolar large rRNA by RNA polymerase I |
| regulation of histone H3-K9 acetylation |
| negative regulation of histone acetylation |
| establishment of protein localization to chromosome |
| positive regulation of TORC1 signaling |
| regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| negative regulation of peptidyl-lysine acetylation |
| negative regulation of histone methylation |
| negative regulation of protein acetylation |
| positive regulation of transcription by RNA polymerase I |
| regulation of histone H3-K9 methylation |
| protein localization to chromatin |
| regulation of histone H3-K4 methylation |
| transcription preinitiation complex assembly |
| positive regulation of histone acetylation |
| regulation of transcription by RNA polymerase I |
| positive regulation of peptidyl-lysine acetylation |
| phosphoprotein binding |
| transcription initiation from RNA polymerase I promoter |
| positive regulation of TOR signaling |
| transcription by RNA polymerase I |
| regulation of TORC1 signaling |
| positive regulation of protein acetylation |
| negative regulation of histone modification |
| regulation of histone acetylation |
| negative regulation of chromatin organization |
| regulation of peptidyl-lysine acetylation |
| protein localization to chromosome |
| regulation of histone methylation |
| regulation of protein acetylation |
| ATPase binding |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| negative regulation of cysteine-type endopeptidase activity |
| positive regulation of histone modification |
| regulation of TOR signaling |
| positive regulation of chromatin organization |
| histone binding |
| negative regulation of chromosome organization |
| regulation of histone modification |
| chromatin remodeling |
| positive regulation of chromosome organization |
| regulation of chromatin organization |
| protein-DNA complex assembly |
| rRNA processing |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| DNA-templated transcription, initiation |
| RNA localization |
| rRNA metabolic process |
| negative regulation of apoptotic signaling pathway |
| ribonucleoprotein complex assembly |
| regulation of cysteine-type endopeptidase activity |
| protein-DNA complex subunit organization |
| negative regulation of endopeptidase activity |
| ribonucleoprotein complex subunit organization |
| positive regulation of protein complex assembly |
| negative regulation of peptidase activity |
| ribosome biogenesis |
| positive regulation of protein serine/threonine kinase activity |
| regulation of chromosome organization |
| negative regulation of proteolysis |
| negative regulation of organelle organization |
| ncRNA processing |
| regulation of apoptotic signaling pathway |
| regulation of endopeptidase activity |
| establishment of protein localization to organelle |
| regulation of peptidase activity |
| regulation of protein complex assembly |
| negative regulation of hydrolase activity |
| ribonucleoprotein complex biogenesis |
| protein kinase binding |
| ncRNA metabolic process |
| regulation of protein serine/threonine kinase activity |
| positive regulation of cellular component biogenesis |
| positive regulation of protein kinase activity |
| positive regulation of kinase activity |
| negative regulation of protein modification process |
| positive regulation of organelle organization |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| positive regulation of transferase activity |
| epithelial cell differentiation |
| chromatin organization |
| negative regulation of cellular component organization |
| regulation of proteolysis |
| protein localization to organelle |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| cellular protein-containing complex assembly |
| nucleolus |
| regulation of kinase activity |
| RNA processing |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| regulation of cellular component biogenesis |
| regulation of transferase activity |
| negative regulation of cell death |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| negative regulation of cellular protein metabolic process |
| positive regulation of phosphorylation |
| chromosome organization |
| nucleobase-containing compound biosynthetic process |
| negative regulation of protein metabolic process |
| epithelium development |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| negative regulation of molecular function |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| regulation of organelle organization |
| organic cyclic compound biosynthetic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| protein-containing complex assembly |
| regulation of programmed cell death |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| negative regulation of response to stimulus |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| RNA metabolic process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| tissue development |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4422
- Expression level (log2 read counts): 6.05
Expression Distribution
PIH1D1 Expression in NALM6 Cells: 6.05
