TCERG1

Gene Information

Official Symbol: TCERG1
Official Name: transcription elongation regulator 1
Aliases and Previous Symbols: N/A
Entrez ID: 10915
UniProt: O14776
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter. {ECO:0000269|PubMed:11604498, ECO:0000269|PubMed:9315662}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Caffeine 2600μM R08 exp463	-2.01
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-1.85
SB203580 25μM R03 exp149	-1.81
UM0130462 0.025 to 0.035μM day4 R05 exp247	-1.72
CI-1040 9.5μM R08 exp472	-1.7
Hinokiflavone 12μM R08 exp487	1.77
SNS-032 25μM R07 exp401	1.82
B02 10μM R08 exp453	1.85
Cytochalasin-B 5μM R07 exp349	1.86
AICAR 240μM R03 exp116	1.87
SB202190 10μM R03 exp148	2
Tozasertib 0.1μM R07 exp414	2.08
Arsenate 40μM R06 exp264	2.54

Global Fraction of Cell Lines Where Essential: 8/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	2/28
bone	0/25
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2116
Expression level (log2 read counts): 7.17

Expression Distribution

RNA polymerase II repressing transcription factor binding
transcription corepressor activity
transcription coactivator activity
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
negative regulation of transcription by RNA polymerase II
identical protein binding
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
organic cyclic compound biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
RNA binding
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
cellular nitrogen compound biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
negative regulation of gene expression
positive regulation of RNA metabolic process
macromolecule biosynthetic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
gene expression
positive regulation of biosynthetic process