TMEM106B

Entrez Summary: N/A
UniProt Summary: Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching. {ECO:0000269|PubMed:23136129, ECO:0000269|PubMed:24357581}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

lysosome localization
dendrite morphogenesis
lysosome organization
lytic vacuole organization
positive regulation of dendrite development
dendrite development
lysosomal transport
late endosome membrane
vacuole organization
vacuolar transport
regulation of dendrite development
lysosome
endosome
positive regulation of neuron projection development
lysosomal membrane
positive regulation of neuron differentiation
positive regulation of cell projection organization
cell morphogenesis involved in neuron differentiation
positive regulation of neurogenesis
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
regulation of neuron projection development
cell part morphogenesis
positive regulation of nervous system development
positive regulation of cell development
cell morphogenesis involved in differentiation
organelle localization
regulation of neuron differentiation
neuron projection development
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
cell morphogenesis
molecular function
neuron development
regulation of neurogenesis
cellular component morphogenesis
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation