AASDH

Entrez Summary: This gene encodes a member of the non-ribosome peptide syntesase (NRPS) enzyme family. The encoded protein contains an AMP-binding domain, PP-binding (phosphopantetheine, or pantetheine 4'phosphate-binding) domain and the Pyrrolo-quinoline quinon (PQQ) binding domain. The protein is expressed in several adult tissues. [provided by RefSeq, Apr 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Trimetrexate 0.03μM R08 exp535	-1.91
∆-9-Tetrahydrocannabinol 30μM R08 exp445	1.71
Thapsigargin 0.005μM R07 exp407	1.74
Latrunculin-B 10μM R07 exp374	1.75
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	1.76
IL-3 9ng/ml R08 exp493	1.77
JQ1 0.8μM R08 exp435	1.82
Ammonium tetrathiomolybdate 10μM R08 exp448	1.83
CVT-10216 0.1μM R06 exp278	1.83
Ibrutinib 10μM R08 exp442	1.86
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.86
Genistein 15μM R07 exp360	1.88
Calcipotriol 5μM R08 exp464	1.89
Beta-Estradiol 0.55μM R07 exp425	2.02

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

AMP-binding
PP-binding

amino acid activation for nonribosomal peptide biosynthetic process
acid-thiol ligase activity
beta-alanine metabolic process
nonribosomal peptide biosynthetic process
amino acid activation
neurotransmitter metabolic process
cellular amino acid metabolic process
fatty acid metabolic process
regulation of neurotransmitter levels
peptide biosynthetic process
amide biosynthetic process
peptide metabolic process
monocarboxylic acid metabolic process
cellular amide metabolic process
carboxylic acid metabolic process
cellular lipid metabolic process
oxoacid metabolic process
organic acid metabolic process
lipid metabolic process
organonitrogen compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process
small molecule metabolic process