AP5S1

Entrez Summary: N/A
UniProt Summary: As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862, it is required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269|PubMed:20613862, ECO:0000269|PubMed:22022230}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Betulinic acid 10 to 15μM on day4 R05 exp222	-2.86
Q15 2.7μM R02 exp79	-2.69
HMS-I1 1μM R01 exp46	-1.95
UM0011500 5μM R05 exp245	-1.73
Vinblastine 0.2μM R03 exp108	1.71
2-Methoxyestradiol 0.2μM R01 exp40	1.76
BI-6727 0.04μM R03 exp98	1.9

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

AP-type membrane coat adaptor complex
double-strand break repair via homologous recombination
recombinational repair
late endosome membrane
late endosome
double-strand break repair
DNA recombination
endosomal transport
lysosome
lysosomal membrane
DNA repair
DNA metabolic process
cellular response to DNA damage stimulus
protein transport
intracellular transport
peptide transport
amide transport
establishment of protein localization
cellular response to stress
establishment of localization in cell
nitrogen compound transport
vesicle-mediated transport