CCDC109B

Official Symbol: MCUB
Official Name: mitochondrial calcium uniporter dominant negative subunit beta
Aliases and Previous Symbols: N/A
Entrez ID: 55013
UniProt: Q9NWR8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. {ECO:0000250|UniProtKB:Q810S1}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.8
Docetaxel 0.002μM R01 exp45	1.86
Nifurtimox 1μM R03 exp141	1.87
Taxol 0.002μM R01 exp54	1.95
2-Methoxyestradiol 0.2μM R01 exp40	2.17

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

uniplex complex
calcium import into the mitochondrion
calcium channel inhibitor activity
intrinsic component of membrane
mitochondrial calcium ion transmembrane transport
calcium channel complex
mitochondrial calcium ion homeostasis
ion channel activity
integral component of mitochondrial inner membrane
calcium ion import
cytosolic calcium ion transport
mitochondrial transmembrane transport
calcium ion transmembrane transport
mitochondrial transport
calcium ion transport
divalent metal ion transport
divalent inorganic cation transport
mitochondrial inner membrane
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
cellular metal ion homeostasis
inorganic cation transmembrane transport
cation transmembrane transport
metal ion homeostasis
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
inorganic ion transmembrane transport
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
ion homeostasis
cation transport
cellular homeostasis
ion transmembrane transport
chemical homeostasis
mitochondrion
transmembrane transport