CDC27

Entrez Summary: N/A
UniProt Summary: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:18485873}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ethanol 0.01 R05 exp234	-2.06
HMS-I2 10μM R06 exp288	-1.79
Nicotine 3000μM R08 exp510	1.74
Resminostat 0.5μM R07 exp393	1.76
∆-9-Tetrahydrocannabinol 30μM R08 exp445	1.87
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	2.02
Cyclosporin-A 3μM R07 exp348	2.11
2-Methoxyestradiol 0.55μM R07 exp310	2.34
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	2.46

Global Fraction of Cell Lines Where Essential: 733/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	27/28
bone	26/26
breast	33/33
central nervous system	55/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	15/16
ovary	26/26
pancreas	24/24
peripheral nervous system	15/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	21/22
urinary tract	29/29
uterus	5/5

Expression Distribution

metaphase/anaphase transition of mitotic cell cycle
metaphase/anaphase transition of cell cycle
anaphase-promoting complex
protein K11-linked ubiquitination
spindle microtubule
regulation of mitotic sister chromatid separation
regulation of chromosome separation
regulation of mitotic sister chromatid segregation
regulation of sister chromatid segregation
anaphase-promoting complex-dependent catabolic process
protein phosphatase binding
regulation of chromosome segregation
regulation of mitotic nuclear division
regulation of nuclear division
mitotic cell cycle phase transition
cell cycle phase transition
protein polyubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
regulation of chromosome organization
regulation of mitotic cell cycle phase transition
regulation of cell cycle phase transition
centrosome
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
mitotic cell cycle process
cellular protein catabolic process
regulation of mitotic cell cycle
mitotic cell cycle
protein catabolic process
protein ubiquitination
regulation of cell cycle process
protein modification by small protein conjugation
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
cell cycle process
macromolecule catabolic process
organonitrogen compound catabolic process