LYPD8
Gene Information
- Official Symbol: LYPD8
- Official Name: LY6/PLAUR domain containing 8
- Aliases and Previous Symbols: N/A
- Entrez ID: 646627
- UniProt: Q6UX82
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis. {ECO:0000250|UniProtKB:Q9D7S0}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 15908
- Expression level (log2 read counts): 0.9
LYPD8 Expression in NALM6 Cells: 0.9
