MVD

Entrez Summary: The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008].
UniProt Summary: Performs the first committed step in the biosynthesis of isoprenes.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 375/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	11/28
blood	20/28
bone	12/26
breast	16/33
central nervous system	13/56
cervix	3/4
colorectal	10/17
esophagus	8/13
fibroblast	0/1
gastric	8/16
kidney	10/21
liver	12/20
lung	42/75
lymphocyte	5/16
ovary	11/26
pancreas	18/24
peripheral nervous system	10/16
plasma cell	8/15
prostate	1/1
skin	12/24
soft tissue	4/9
thyroid	1/2
upper aerodigestive	10/22
urinary tract	14/29
uterus	2/5

Expression Distribution

diphosphomevalonate decarboxylase activity
isopentenyl diphosphate biosynthetic process, mevalonate pathway
isopentenyl diphosphate biosynthetic process
isopentenyl diphosphate metabolic process
dolichyl diphosphate metabolic process
dolichyl diphosphate biosynthetic process
dolichol-linked oligosaccharide biosynthetic process
oligosaccharide-lipid intermediate biosynthetic process
isoprenoid biosynthetic process
acetyl-CoA metabolic process
Hsp70 protein binding
cholesterol biosynthetic process
secondary alcohol biosynthetic process
regulation of sterol biosynthetic process
regulation of cholesterol biosynthetic process
sterol biosynthetic process
regulation of cholesterol metabolic process
regulation of alcohol biosynthetic process
protein N-linked glycosylation
regulation of steroid biosynthetic process
thioester metabolic process
acyl-CoA metabolic process
peroxisome
alcohol biosynthetic process
regulation of steroid metabolic process
cholesterol metabolic process
steroid biosynthetic process
secondary alcohol metabolic process
purine nucleoside bisphosphate metabolic process
nucleoside bisphosphate metabolic process
ribonucleoside bisphosphate metabolic process
sterol metabolic process
isoprenoid metabolic process
organic hydroxy compound biosynthetic process
regulation of lipid biosynthetic process
phospholipid biosynthetic process
coenzyme metabolic process
protein glycosylation
macromolecule glycosylation
steroid metabolic process